000			01819cam a22003738i 4500
999			_c287973 _d287973
001			20869899
003			OSt
005			20230626162409.0
008			190228s2019 flu b 001 0 eng
010			_a 2019003924
020			_a9781439837177
040			_aDLC _beng _erda _cMUL
042			_apcc
050	0	0	_aQH324.2 _b.A46 2019
082	0	0	_a570.113 _223 _bALO
100	1		_aAlon, Uri, _d1969- _eauthor. _912176
245	1	3	_aAn introduction to systems biology : _bdesign principles of biological circuits / _cUri Alon.
250			_aSecond edition.
263			_a1907
264		1	_aBoca Raton, Fla. : _bCRC Press, _c[2019]
300			_axviii, 324pages ; _bill., _c26 cm.
336			_atext _btxt _2rdacontent
337			_aunmediated _bn _2rdamedia
338			_avolume _bnc _2rdacarrier
504			_aIncludes bibliographical references and index.
505	0		_aPart one: Network motifs -- Transcription networks basic concepts -- Autoregulation -- The feed forward loop -- Temporal programs and the global structure of transcription networks -- Positive feedback, bistability and memory -- How to build a biological oscillator -- Robustness -- Kinetic proofreading and conformational proofreading -- Part two: Robust signalling -- Chemotaxis -- Fold-change detection -- Dynamical compensation and mutal resistance in tissues -- Robust spatial patterning in development -- Part three: Optimality -- Optimal gene circuit design -- Multi-objective optimality in biology -- Modularity.
650		0	_aSystems biology. _95173
650		0	_aComputational biology. _912156
650		0	_aBiological systems _xMathematical models. _912177
906			_a7 _bcbc _corignew _d1 _eecip _f20 _gy-gencatlg
942			_2ddc _cBK